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KMID : 0357920110450020205
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Korean Journal of Pathology
2011 Volume.45 No. 2 p.205 ~ p.208
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A Metastatic Granulocyte Colony-Stimulating Factor Producing Sarcomatoid Carcinoma of the Lung Causing Jejunal Intussusception - Report of a Case -
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Hong Min-Eui
Hong Soon-Auck
Kwon Gui-Young
Lee Tae-Jin
Park Eon-Sub
Cha Sung-Jae
Do Jae-Hyuk
Yoo Jae-Hyung
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Abstract
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A 75-year-old man was referred to our hospital with intestinal obstruction caused by intussusception. Abdominal computed tomography (CT) revealed seven polypoid masses in the small intestine, while chest CT revealed a mass in the right lower lobe. Preoperative laboratory tests showed white blood cell (WBC) and neutrophil differential counts of 63,630/mm³ and 95%, respectively. The serum granulocyte colony-stimulating factor (G-CSF) was 114 pg/mL, which was elevated (normal range, <18.1 pg/mL). After resection of the small bowel, the WBC count decreased to 20,510/mm³. The pathology showed a poorly differentiated carcinoma with sarcomatous components confirmed by positive immunostaining of cytokeratin (AE1/AE3) and vimentin in the small intestine. Furthermore, immunohistochemistry with specific monoclonal antibodies against G-CSF was positive. A lung biopsy revealed the same histological findings as the small intestine lesion. Therefore, the patient was diagnosed as having a G-CSF producing sarcomatoid carcinoma of the lung with metastasis to the small intestine.
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KEYWORD
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Carcinosarcoma, Granulocyte colony-stimulating factor, Metastasis, Intussusception
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